NIH In the standard evaluation of the kidney, there were slightly increased incidences of renal tubule adenoma and renal tubule adenoma or carcinoma (combined) in males exposed to 900 or 1,800 ppm, and renal tubule carcinoma in males exposed to 1,800 ppm. Dick RB, Krieg EF Jr, Setzer J, Taylor B. Fundam Appl Toxicol. Production. BrdU labeling; CAR/PXR; Knockout mice; Mode of action; Rodent liver.
Both gross and microscopic evidence of lung damage were reported in acute inhalation toxicity studies in animals. Int J Toxicol. Constitutive androstane receptor (CAR) nuclear receptor-mediated activation has been hypothesized as the MOA for MIBK-induced mouse liver tumorigenesis.
| The incidences of renal tubule hyperplasia were also significantly increased in the 450 and 1,800 ppm males, and the severities were greater than in the chamber controls. 2004;23 Suppl 1:29-57. doi: 10.1080/10915810490274298. Find NCBI SARS-CoV-2 literature, sequence, and clinical content: https://www.ncbi.nlm.nih.gov/sars-cov-2/. Clipboard, Search History, and several other advanced features are temporarily unavailable. HHS
uuid:86434afb-f520-40d9-965a-aa80f4964392 The relative pulmonary uptake of MIBK was about 60% and the total uptake increased linearly with increasing exposure concentration.
There was a positive trend in the incidences of mononuclear cell leukemia in males, and the incidence in the 1,800 ppm group was significantly increased. Natl Toxicol Program Tech Rep Ser.
Epub 2017 Feb 20.
In clinical tests, most of the absorbed MIBK had been eliminated from the body 90 min post exposure. 2. New York, NY: Interscience Publishers, Inc., p. 1738. LEL(@200 F): 1.2% (10% LEL(@200 F), 1,200 ppm). -. 2nd rev. Methyl isobutyl ketone is used as a solvent for gums, resins, paints, varnishes, lacquers, and nitrocellulose. This may be a conservative value due to the lack of relevant acute toxicity data for workers exposed to concentrations above 500 ppm. COVID-19 is an emerging, rapidly evolving situation. II. Natl Toxicol Program Tech Rep Ser.
Clinical observations and blood chemistry tests among workers exposed to the effect of a complex ketone methyl-isobutyl …
In: Hygienic guide series.
Also, AIHA  reported that exposure of rats to 4,000 ppm for 4 hours killed 6 of 6 and exposure at 2,000 ppm for 4 hours killed 0 of 6 [Smyth et al.
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Only 0.04% of the total MIBK dose was eliminated unchanged via the kidneys within 3 h post exposure.
The mean body weights of females exposed to 1,800 ppm were less than those of the chamber controls after week 17. Methyl isobutyl ketone (MIBK) is the organic compound with the formula (CH 3) 2 CHCH 2 C(O)CH 3. 2014 May;44 Suppl 2:15-24. doi: 10.3109/10408444.2014.910751. The incidence of adrenal medulla hyperplasia in the 1,800 ppm males was significantly increased. 2008;27 Suppl 4:107-38. doi: 10.1080/10915810802550835. CDC twenty four seven. 2008 Feb 28;244(2-3):209-19. doi: 10.1016/j.tox.2007.11.014.
3. The toxicokinetics as well as irritative effects and CNS symptoms of methyl isobutyl ketone (MIBK) were studied in human volunteers during inhalation exposure. NIOSH REL: 50 ppm (205 mg/m3) TWA, 75 ppm (300 mg/m3) STEL, Current OSHA PEL: 100 ppm (410 mg/m3) TWA, 1989 OSHA PEL: 50 ppm (205 mg/m3) TWA, 75 ppm (300 mg/m3) STEL, 1993-1994 ACGIH TLV: 50 ppm (205 mg/m3) TWA, 75 ppm (307 mg/m3) STEL. Accordingly, the panel continues to support MIBK’s removal from the CAA HAPs list. Mode of action and human relevance analysis for nuclear receptor-mediated liver toxicity: A case study with phenobarbital as a model constitutive androstane receptor (CAR) activator. Among a group of workers exposed to concentrations of 500 ppm for 20 to 30 minutes and about 80 ppm for the rest of the shift, most experienced irritation of the eyes, nose, and throat, weakness, loss of appetite, headache, nausea, vomiting, and a sore throat [Linari et al. Am Ind Hyg Assoc Q 17(2):129-185. 2008 Nov;52(2):180-8. doi: 10.1016/j.yrtph.2008.08.007.
1987 May;44(5):292-308 Get the latest public health information from CDC: https://www.coronavirus.gov. Basis for revised IDLH: The revised IDLH for hexone is 500 ppm based on acute inhalation toxicity data in humans [Linari et al. Short-term and subchronic inhalation exposures (as low as 100 ppm) produced effects in the kidney and liver that were species and sex dependent. 5. Methyl isobutyl ketone.
1992 Oct;19(3):453-73. doi: 10.1016/0272-0590(92)90185-k. An ongoing carcinogenicity study of MIBK being conducted by the National Toxicology Program will be considered when the results are available. Scand J Work Environ Health. Get the latest research from NIH: https://www.nih.gov/coronavirus.
NCI CPTC Antibody Characterization Program. Textures¨ 2.0: LaserWriter 8 Z1-8.7 1946]. Get the latest research from NIH: https://www.nih.gov/coronavirus.
Neurotoxic interactions of industrially used ketones.
It is also used as a …
1321-74-0) in F344/N rats and B6C3F1 mice (inhalation studies).
Toxicology. Genetic toxicology studies were conducted in Salmonella typhimurium. Amended final report of the safety assessment of t-Butyl Alcohol as used in cosmetics. The incidences of eosinophilic foci were significantly increased in 450 and 1,800 ppm females. Survival of males exposed to 1,800 ppm was significantly less than that of the chamber controls. The concentration of unchanged MIBK in the urine after exposure was proportional with the total uptake.
| FUNDAMENTAL AND APPLIED TOXICOLOGY 9, 380-388 (1987) A 14-Week Vapor Inhalation Toxicity Study of Methyl Isobutyl Ketone' RICHARD D. PHILLIPS, *,2 ELIZABETH J. MORANJ DAROL E. DODD,$ EDWARD H. FOWLER,t CHRISTINA D. KARY,3 AND JOHN O'DONOGHUE 11 *Exxon Biomedical Sciences, Inc., East Millstone, New Jersey 08873; tChemical Manufacturers Association, Washington, …